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KMID : 0376219640010010059
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Chonnam Medical Journal
1964 Volume.1 No. 1 p.59 ~ p.63
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Compartmental Distribution and Shift of Water and Electrolytes in Cirrhosis of the Liver
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Abstract
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The sodium, potassium and chloride concentrations in the serum and ascitic fluid of patients with liver cirrhosis were determined together with the measurement of exchangeable Na and K contents by the isotope kilution technique.
The sodium concentration in the ascitic fluid was significantly higher than in the serum which showed hyponatremia. In contrast, the ascitic fluid chloride concentration was lower than in the werum showing hypochloremia. With regard to potassium concentration, there could be found no significant difference between the serum and ascitic fluid.
The serum exchaneable Na content showed a gradual decrease with a concomitant increase in the ascitic fluid as a function of time between 18 and 24 hours after the isotope administration. The exchaneable K content showe dthe similar tendency, although of smaller magnitude as compared with the exchaneable Na.
From these results it is construed that a shift and sequestration of sodium from the vascular into the extravascular, peritoneal space occurs in cirrhosis of the liver with ascites.
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